Efficacy of fixed minidose warfarin prophylaxis in total hip replacement.
نویسندگان
چکیده
OBJECTIVE To determine whether a small fixed perioperative dose of warfarin would prevent deep vein thrombosis after total hip replacement. DESIGN Prospective, randomised, double blind placebo controlled trial. SETTING Winford Orthopaedic Hospital, Bristol. SUBJECTS 148 patients having primary total hip replacement. INTERVENTION Warfarin 1 mg given daily for one week before and three weeks after surgery. MAIN OUTCOME MEASURE Deep vein thrombosis diagnosed by the iodine-125 labelled fibrinogen uptake method. RESULTS Deep vein thrombosis occurred in 25 (34%) of the patients given warfarin and 19 (26%) of the controls (difference 8%; 95% confidence interval -6.8% to 22.8%). CONCLUSION Fixed minidose warfarin does not prevent deep vein thrombosis after total hip replacement.
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ورودعنوان ژورنال:
- BMJ
دوره 303 6796 شماره
صفحات -
تاریخ انتشار 1991